Is the camera moving? If it's a still shot you could make a clean plate of the empty city in Photoshop and use a green screen for the actor. If you don't want the shot locked-off you can cheat add some movement to the frame in post, but big changes in perspective would require recreating the city in 3D.
Interestingly one of the earliest photographs of a ...
I not know how do this with AE animation software but I do this in Blender:
Basic theory (see picture) for real camera or software:
• Want repeat image every n animation frames
• Assume camera view is w × h pixels
• For camera view w pixels wide, minimum need draw picture wide 2w pixels wide
• Copy picture two times and ...